What is D-Aspartic Acid?

The isomeric L-Aspartic Acid is known as DAA, or D-Aspartic Acid. In the world of sports supplements, it is an absolute hit! DAA is specifically associated with a receptor group found in the anterior of the brain because it possesses a particular metabolism. It is later on converted to NMDA, or N-Methyl D-Aspartate, once metabolized in the body.

DAA is very popular in the sports supplements world because it helps to increase the body’s levels of gonadotropin, luteinizing hormone, and even hormones that stimulate follicles. As a result, it helps to boost your body’s levels of testosterone, thus helping you to grow your muscles and your strength as well. However, there may be a caveat…

The receptors for NMDA in your brain are the ones that are responsible when it comes to operative conditioning – a human behavior. Operative conditioning is what allows us, humans, to experience changes in our environment and adapt to them as well. Because of these receptors, we get a sense of fulfillment when we successfully complete a task. If these receptors fail or stop working, it is at this time that humans begin to develop central nervous system ailments and conditions such as Alzheimer’s.

DAA is something that was discovered 50+ years ago, and during the half-century of its existence, it was discovered that DAA can kill the brain’s NMDA receptors through overexcitement.

So yes, while you can use D-Aspartic Acid to help boost your testosterone, you could end up giving yourself some problems. Is that worth it trade? Today we are here to give you all the information you need so you can assess the risk-benefit ratio yourself.

What Exactly is DAA?

D-aspartic acid, sometimes also known as D-asparagine, can sometimes be labeled as D-aspartate. This substance is often used as an ingredient in testosterone-boosting supplements on the market. DAA is basically one of the many amino acids and is essentially an L-asparagine spatial isomer. L-aspartic acid, the amino acid’s left form, is just one of the 20 amino acids that are protein-forming. This amino acid can be found in mammals and humans – in practically all of the proteins.

More Info About D-Aspartate

The D form or right form of DAA is basically metabolized in NMDA or N-methyl-D-aspartate, the substance that causes stimulation to the brain’s NMDA receptors. The effect is similar to that of MSG, but to a lesser extent.

The NMDA receptors in the brain are biological structures and are related to the brain synapses’ plasticity. They are also related to the brain’s capacity for memory. The testing and learning of human emotions are also connected to receptors.

However, the more you excite these receptors, the more problems you can cause – you can end up causing a problem of excitotoxicity. This is where the substances cause far too much excitement in the receptors which results in the destruction of the cells.

Chemical Structure of D-Aspartic Acid

C4H7NO4 – this is DAA’s molecular formula. It has a molecular mass of 133.103g/mol. The IUPAC name is 2-Aminobutanedioic acid. This acid is also known as asparaginic acid, asparagic acid, and aminosuccinic acid.

Aspartic acid has two enantiomers or forms – D and L. An enantiomer is basically 1 of 2 stereoisomers which are mirror images of one another but are not identical. Out of the L and D enantiomers, only the L form is turned by the body into proteins. D-aspartic acid has more limited biological roles. Racemic mixture, which is the mixture of L and D aspartic acid (DL-Aspartic Acid) is created through most chemical synthesis processes.

What is D-Aspartic Acid Used For?

D-aspartate, D-sodium-aspartate, as well as N-Methyl-D-aspartate, all perform neurotransmission and neuromodulation functions. The synthesis of enzyme proteins and signal proteins in the body’s nerve cells is also stimulated by this substance.

DAA is often associated with the regulation of hormones in the body (endocrine system). It is also found to be a stimulant when it comes to synthesizing enzymes that boost testosterone production.

What Are The Benefits of D-Aspartic Acid?

Despite the scary effects that DAA may have, it does have its many benefits! For example, it can increase luteinizing hormone as well as testosterone synthesis. It helps to increase your aromatase synthesis because of the resulting boost in testosterone. Aromatase is basically a key enzyme in the process of estrogen synthesis.

In lab animals as well as in cell cultures, other benefits have also been found. Here are some of them:

  • Prolactin synthesis was found to be increased in lab rats. It is being tested in humans, but human studies are currently still in the early stages. However, similar effects are expected.
  • Growth hormone synthesis is increased. The hormone that releases gonadotropin is also boosted. This is not yet tried and tested in humans, however.
  • Progesterone production is increased in both animals and humans.
  • GABA (gamma-aminobutyric acid) release is stimulated. GABA, an amino acid, is made in the brain. It’s associated with concentration and calmness. It can help sufferers of chronic anxiety because it prevents overstimulation of neurons. It can also induce relaxation of muscles. The deficiency of GABA can cause convulsions and cramps.

On top of all of that, there are also some unauthorized claims when it comes to the benefits of DAA. One such claim is that DAA supposedly helps to permanently increase levels of testosterone.

How Does DAA Function?

DAA boosts cGMP and cAMP, which are both signaling proteins. Leydig cells are where cAMP proteins are synthesized. The main function of these Leydig cells is synthesizing sex hormones such as progesterone and testosterone. Thus, cAMP stimulates and boosts progesterone and testosterone production – up to thirty percent.

On the other hand, cGMP increases growth hormone, prolactin, and luteinizing hormone synthesis.

Inside the hypothalamus, DAA improves GnRH release. GnRH (Gonadotropin-releasing hormone) is responsible for releasing FSH (follicle-stimulating hormone) as well as luteinizing hormone. It also stimulates oxytocin and vasopressin release, while simultaneously stimulating matrix RNA synthesis.

In essence, DAA stimulates the synthesis of proteins cGMP, cAMP, and StAR.

DAA boosts testosterone production for sure, but at the same time, aromatase becomes the problem. Aromatase, the enzyme which turns excess T into estrogen, nullifies the effects of DAA if you do not take them with aromatase inhibitors.

What Are The Side Effects of DAA?

DAA along with its analogs are considered to be exotoxins (like MSG & aspartame) because they overstimulate the brain’s NMDA receptors. If overstimulation occurs, cell death can be the result. Thus if you have a hereditary or genetic predisposition to any neuro-degenerative conditions, we advise that you steer clear of exotoxins.

What Are The Recommended DAA Doses?

If taken as a supplement, only one dose of DAA is validated scientifically for human use. That is 10mL of 2 M (3.12g/10ml) sodium D-aspartate. It has to be taken alongside folic acid, B12 and B6, for a 12 day period. If you take a higher dose or if you take it without the recommended vitamins, you can end up seriously damaging your body. More NMDA cells will be destroyed and as a result, you will end up at risk of developing far more diseases. Do not take NMDA for longer than 12 days, either!

Are There Any D-Aspartic Acid Contraindications?

If you are a pregnant woman, steer clear. The same goes for women who are breastfeeding. Also, take note that excitotoxicity risk increases along with the amount you take in. The age of the person who takes the DAA is also part of the equation. If you have predispositions to neurodegenerative conditions or if you currently have one, do not take this supplement.

What Supplements Have DAA?

You will often see D-Apartic Acid in supplements made to stimulate libido or hormone production. It is also often found in supplements for fertility. Usually, it is combined with inhibitors for aromatase, as well as with B-vitamins and other stimulating agents that boost testosterone production.

DAA is also found in other products such as in hormonal stimulants and products with precursors for energy (creatine) and nitric oxide.

None of these products will mention any of the exotoxic side effects that DAA may have, but now that you are aware of them, you can make a more informed decision on whether you want to continue taking the product or not.


DAA is essentially a booster for testosterone which has recently seen a boost in popularity. Animal research has found that it is extremely powerful, but it still remains in the early stages of human testing.

Because of this, DAA is much more dangerous in comparison to the other T boosting products that have already been tested clinically and on humans.

Regardless, the choice is still yours whether you want to take this supplement or not. If you don’t want to start using it just yet, there is also no harm in waiting until human trials progress sooner. Also, we suggest that if you want to try this supplement, you should consult your doctor before you begin.